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KMID : 0104920210300020024
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Journal of Hawhwa Medicine
2021 Volume.30 No. 2 p.24 ~ p.32
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A Study on Glycemic Control Functional Material Using Mulberry Leaves Gami Saengmaek-san
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Seo Min-Young
Kim Dong-Hee
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Abstract
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This study aims to investigate the effects of Mulberry Leaves Gami Saengmaek-san (MLGS) on blood glucose and lipid metabolism in type 2 diabetic mellitus mice, and to evaluate its use as a functional material for glycemic control. MLGS consists of Saengmeak-san composed of Liriope platyphylla Wang et Tang, Schisandra chinensis Baillon and Panax ginseng C.A. Meyer with Morus alba Linne added, which have been proven to have antidiabetic properties. We researched the effects of MLGS in type 2 diabetic mellitus mice. C57BL/6 mouse groups had no treatment, db/db mouse randomly assigned to 4 groups, 2 groups of the control group treated with distilled water, 1 mg/kg of glimepiride and 2 groups of the experimental group treated with MLGS (200 and 400 mg/kg/day). After 4 weeks of treatment, blood glucose levels and body weight were checked. Liver function indicators (AST, ALT, ALP and LDH) and lipid metabolites (total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides) were measured with a biochemistry analyzer. Diabetic factors (insulin,
resistin, leptin, and adiponectin) were measured with ELISA. MLGS significantly decreased body weight, fasting blood glucose, liver function indicators (AST, ALT, ALP, and LDH), lipid metabolites (total cholesterol, LDL cholesterol, and triglycerides), and diabetic factors (insulin and resistin). Also, leptin and adiponectin were significantly increased in the MLGS group, and HDL-cholesterol was increased, but there was no significant difference with the control group. MLGS may have the potential to improve diabetes mellitus by regulating blood glucose levels and diabetic factors. Also protecting from diabetic complications by adjusting liver function indicators and lipid metabolites. These results suggest that MLGS can be used as a functional food for diabetes.
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KEYWORD
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Diabetes, Glycemic control, Saengmeak-san, Mulberry leaves, Functional food
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